![]() ![]() Urine (small amounts as unchanged drug) Note: At therapeutic doses, elimination occurs rapidly via nonrenal mechanisms. MetabolismĬomplex thought to occur by depolymerization and desulphation via the reticuloendothelial system primarily in the liver and spleen (ACCP Dawes 1979 Estes 1980 Kandrotas 1992) Excretion Premature neonates (data based on single dose of 100 units/kg within 4 hours of birth) (McDonald 1981): Inversely proportional to gestational age (GA).Īdults: Following a single 75 unit/kg dose: 36.6 ± 7.4 mL/kg (McDonald 1981). Oral, rectal: Erratic at best from these routes of administration SubQ absorption is also erratic, but considered acceptable for prophylactic use Distribution Potentiates the action of antithrombin III and thereby inactivates thrombin (as well as other coagulation factors IXa, Xa, XIa, XIIa, and plasmin) and prevents the conversion of fibrinogen to fibrin heparin also stimulates release of lipoprotein lipase (lipoprotein lipase hydrolyzes triglycerides to glycerol and free fatty acids) Pharmacokinetics/Pharmacodynamics Absorption Solution Prefilled Syringe, Injection, as sodium : ![]() Generic: 10 units/mL (1 mL, 3 mL, 5 mL) 100 units/mL (1 mL, 3 mL, 5 mL) Excipient information presented when available (limited, particularly for generics) consult specific product labeling. ![]()
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